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KMID : 0363220130510120956
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Korean Journal of Dermatology
2013 Volume.51 No. 12 p.956 ~ p.959
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Clinical Value of Hepatitis Screening and Liver Function Test in Korean Patients with Lichen Planus
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Yoo Min-Gun
Park Jae-Beom
Jang Hee-Won
Lee Sang-Geun
Son Sang-Wook
Kim Il-Hwan
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Abstract
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Background: The relationship between viral hepatitis and lichen planus (LP) remains as a matter of controversy.
Geographical variations are suggested to be a major factor influencing such association. Reliable figures fromKorean patients are still lacking.
Objective: The aim of this study is to determine the prevalence of hepatitis B virus (HBV) and hepatitis C virus(HCV) infections in Korean patients with lichen planus (LP) and to compare it with patients without LP.
Methods: The retrospective study was performed on 45 LP patients and 45 controls with matching age and gender.
We examined for serological evidences of hepatic disease, hepatitis B surface antigen (HBsAg), and anti-HCVseropositivity. Statistical analysis was calculated by using an unpaired t-test and Fisher’s exact test.
Results: No significant differences between the serum levels of alanine aminotransferase (ALT), and aspartateaminotransferase (AST) were observed between the two groups. The prevalence of HBsAg in LP patients (4.4%)was not significantly higher (p＞0.05) than those of the control subjects (2.2%). None of the patients with LP northe control subjects had Anti-HCV.
Conclusion: Korean patients with LP did not have any significant associations with liver diseases or HBV, andHCV infections. Although a large-scale multicenter study is needed to support our results, it is not advisable forKorean patients with LP to be tested for liver functions or HBV, and HCV infections as part of a routine screeningtest.
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KEYWORD
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Hepatitis, Korean, Lichen planus, Liver function
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